Fina Biosolutions社 キャリアタンパク質 Qβ VLP関連商品



Details: Qß1-VLP based anti-fungal peptide vaccines induce robust immunity

商品 容量
Qβ VLP 1 mg, 5 mg


  1. Rashidijahanabad, Z.; Kelly, M.; Kamruzzaman, M.; Qadri, F.; Bhuiyan, T. R.; McFall-Boegeman, H.; Wu, D.; Piszczek, G.; Xu, P.; Ryan, E. T.; Huang, X.

    “Virus like particle display of Vibrio cholerae O-specific polysaccharide as a potential vaccine against cholera”

    ACS Infect. Dis. 2022, 8 (3), 574–583.

  2. Sungsuwan, S.; Wu, X.; Kavunja, H.; McFall-Boegeman, H.; Lang, S.; Rashidijahanabad, Z.; Nick, S. T.; Shaw, V.; Yin, Z.; Jin, X.; Huang, X.

    “Structure Guided Design of Bacteriophage Qβ Mutants as Next Generation Carriers for Conjugate Vaccines”

    ACS Chem. Biol., 2022, in press.

  3. Wu, X.; Ye, J.; Kavunja, H.; DeLaitsch, A.; Rashidijahanabad, Z.; Lang, S.; Kakeshpour, T.; Zhao, Y.; Ramadan, S.; Vilar Saavedra, P.; Yuzbasiyan-Gurkan, V.; Cao, H.; Gildersleeve, J. C.; Huang, X.

    “Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome Hydrolytic Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development”

    Angew. Chem. Int. Ed. 2021, 60, 24179-24188.

  4. Wu, X.; McFall-Boegeman H.; Rashidijahanabad, Z.; Liu, K.; Pett, C.; Yu, J.; Schorlemer, M.; Ramadan, S.; Behren, S.; Westerlind, U.; Huang, X.

    “Synthesis and Immunological Evaluation of the Unnatural β-linked Mucin-1 Thomsen-Friedenreich Conjugate”

    Org. Biomol. Chem. 2021, 19, 2448-2455.

  5. Wang, P.; Huo, C.-X.; Lang, S.; Caution, K.; Nick, S. T.; Dubey, P.; Deora, R.; Huang, X.

    “Chemical Synthesis and Immunological Evaluation of a Pentasaccharide Bearing Multiple Rare Sugars as a Potential Antipertussis Vaccine.”

    Angew. Chem. Int. Ed. 2020, 59, 6451–6458.

    Highlighted in Synfacts 2020, 16, 0471.

  6. Dhara, D., Baliban, S. M.; Huo, C.-X.; Rashidijahanabad, Z.; Sears, K. T.; Nick, S. T.; Misra, A. K.; Tennant, S. M.; Huang, X.

    “Syntheses of Salmonella Paratyphi A Associated Oligosaccharide Antigens and Development towards Anti-Paratyphoid Fever Vaccines.”

    Chem. Eur. J. 2020, 26, 15953-15968.

  7. Wu. X.; McKay, C.; Pett, C.; Yu, J.; Schorlemer, M.; Ramadan, S.; Lang, S.; Westerlind, U.; Finn, M. G.; Huang, X.

    “Synthesis and Immunological Evaluation of Disaccharide Bearing MUC-1 Glycopeptide Conjugates with Virus-like Particles.”

    ACS. Chem. Biol. 2019, 14, 2176-2184.

    This work has been highlighted as the cover of the issue.

  8. Huo, C.-X.; Dhara, D., Baliban, S. M.; Nick, S. T.; Tan, Z.; Simon, R.; Misra, A. K.; Huang, X.

    “Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines.”

    Chem. Commun. 2019, 55, 4519-4522.

  9. Wu. X.; Yin, Z.; McKay, C.; Pett, C.; Yu, J.; Schorlemer, M.; Gohl, T.; Sungsuwan, S.; Ramadan, S.; Baniel, C.; Allmon, A.; Das, R.; Westerlind, U.; Finn, M. G.; Huang, X.

    “Protective Epitope Discovery and Design of MUC1-based Vaccine for Effective Tumor Protections in Immunotolerant Mice.”

    J. Am. Chem. Soc. 2018, 140, 16596-16609.

  10. Yin, Z.; Wu. X.; Kaczanowska, K.; Sungsuwan, S.; Comellas-Aragones, M.; Pett C., Yu J.; Baniel, C.; Westerlind, U.; Finn, M. G.; Huang, X.

    “Antitumor Humoral and T Cell Responses by Mucin-1 Conjugates of Bacteriophage Qβ in Wild-type Mice.”

    ACS Chem. Biol. 2018, 13, 1668-1676.

  11. Yin, Z.; Dulaney, S.: McKay, C. S.; Baniel, C.; Kaczanowska, K.; Ramadan, S.; Finn, M. G.; Huang, X.

    “Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qb, and the Induction of Anticancer Antibodies.”

    ChemBiochem 2016, 17, 174-180.

  12. Yin, Z.; Chowdhury, S.; McKay, C.; Baniel, C.; Wright, W. S.; Bentley, P.; Kaczanowska, K.; Gildersleeve, J. C.; Finn, M. G.; BenMohamed, L.; Huang, X.

    “Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine.”

    ACS Chem. Biol. 2015, 10, 2364-2372.

    This work has also been highlighted in the October 2015 POD cast from ACS Chemical Biology.

  13. Yin, Z.; Comellas-Aragones, M.; Chowdhury, S.; Bentley, P.; Kaczanowska, K.; BenMohamed, L.; Gildersleeve, J. C.; Finn, M.G.; Huang, X.

    “Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids.”

    ACS Chem. Biol. 2013, 8, 1253-1262.

    This work has been highlighted by Chemical & Engineering News, as well as in the June 2013 POD cast from ACS Chemical Biology.

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