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株式会社 東京未来スタイル
(Tokyo Future Style, Inc.)

〒305-0047
茨城県つくば市千現2-1-6
つくば研究支援センター A-13

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GenomeMe社のリファレンスパネルです。病理研究の抗体選定にご活用ください。

(GenomeMe社の製品は試験研究用です。診断やその他の用途ではご使用いただけません。)

 

 

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病理リスト

 

 

 

 

 

 

 

 

 


 

婦人科病理

 

乳癌

 

  CA15-3 CA 19-9 CK 5 CK 7 CK 20 ER/PR p63 CD117
Infiltrating Ductal Carcinoma + - - + - + - -
Adenoid Cystic Carcinoma + + + + - - + +

 

 

頚がん

  BCL2 CK 17 Ki-67 MCM3
Cervical Intraepithelial Neoplasia - - + +
Tubo-Endometrial Metaplasia + + - -
Microglandular Hyperplasia - - - -

 

 

頸部腫瘍

 

  CK 8 CK 17 p16
CIN I -/+ -/+ +
CIN II -/+ + +
CIN III + + +

 

 

卵巣がん

 

  CA-125 CEA PAX-8 WT1
Ovarian CA, Serous + + + +
Ovarian CA, Mucinous - - - -
Ovarian CA, Endometrioid + - + -
Ovarian CA, Clear Cell + - + -

 

 

胎盤栄養膜細胞

 

  1st Trimester 2nd Trimester 3rd Trimester
hCG hPL hCG hPL hCG hPL
Cytotrophoblast - - - - - -
Intermediate Trophoblast 1-24% 25-49% -/+ 50-74% 1-24% 1-49%
Syncytiotrophoblast >75% 1-24% 25-49% 50-74% 1-24% >75%

 

 

胎盤栄養膜増殖

 

  CK
OSCAR
hCG hPL p57 PLAP Vimentin
Partial Mole + -/+ -/+ + + -
Complete Mole + + -/+ - -/+ -
Choriocarcinoma + + -/+ - -/+ -/+
Placental Site Tumor +  +/- + + + +

 

 

性索性間質腫瘍

 

  Calretinin CD99 CK 7 EMA Inhibin MART-1 Vimentin
Granulosa Cell Tumors + + - - + + +
Sertoli-Leydig Cell Tumors + + + - + + +
Gynandroblastoma + -/+     +   +
Gonadoblastomas + + - - + - +

 

 

子宮: 栄養膜増殖

 

  CK Cocktail hCG hPL p57 PLAP Vimentin
Partial Mole Strong, difuse Weak, difuse Weak, difuse + + -
Complete Mole Strong, difuse Strong, difuse Weak, focal - Weak, focal -
Choriocarcinoma Strong, difuse Strong, difuse Weak, focal - Weak, focal -/+
Placental Site Tumor Strong, difuse Strong, focal Strong, difuse   Strong, difuse Strong, difuse

 

 

 

 

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皮膚病理

 

皮膚腫瘍

 

  AR BCL2 CD10 CD34 CK 15 CK 19 CK 20 Ber-EP4
Basal Cell Carcinoma + + + - - + - +
Trichoepithelioma - + - + + + + +
Merkel Cell Carcinoma - + - - - + + +
Microcystic Adnexal Carcinoma - +  +/- - + + - -/+
Sebaceous Carcinoma + -/+  +/- -   - - +
Sebaceous Adenoma + + - -   - - +

 

 

 

 

メラノーマ

 

  Nestin SOX-10 HMB-45 S-100
Desmoplastic Melanoma + + - +
Conventional Melanoma + + + +

 

 

 

 

メルケル細胞がん vs 皮膚小細胞腫瘍

 

 

  CD117 CK
Cocktail
CK 5&6 CK 20 Vimentin Chromogranin
A
Merkel Cell Carcinoma + + - + - +
Small Cell Carcinoma  +/- + - - - +
Lymphoma - - - -  +/- -
Small Cell Melanoma + - - - + -
Squamous Cell Carcinoma - + + - - -

 

メルケル細胞がん vs 皮膚小細胞腫瘍 (続き)

  HMB-45 Neurofilament Synaptophysin TTF-1 CD45 S-100
Merkel Cell Carcinoma - + + - - -
Small Cell Carcinoma - - + + - -
Lymphoma - - - - + -
Small Cell Melanoma + - - - - +
Squamous Cell Carcinoma - - - - - -

 

 

 

皮膚付属器腫瘍

 

  CD15 CK 7 CK 20 EMA BRST-2 S-100
Merkel Cell Carcinoma - - + + - -
Sebaceous Tumor + + - - - -
Apocrine Tumor  +/- + -  +/- + -
Eccrine Tumor - + - + - +

 

 

 

皮膚:基底細胞がん VS 扁平上皮細胞がん

 

  BCL2 CK
8&18
CK
Cocktail
EMA Ep-CAM MOC-31 UEA-1
Basal Cell Carcinoma + -/+ + - + + -
Squamous Cell Carcinoma - - + + - - +

 

 

皮膚:隆起性皮膚線維肉腫 vs Dermatofibroma Fibrous Histiocytoma

 

  CD10 CD34 CD163 CK
Cocktail
Desmin Factor
XIIIa
NGFR p63 S-100
DF-SP  +/- + - - - - + - -
DF-FH + - - - - + - - -

 

 

皮膚:パジェトイド腫瘍

 

  CEA CK,
HMW
CK,
LMW
S-100 Vimentin
Melanoma - - - + +
Paget’s Disease + - + -/+ -
Bowen’s Disease - + + - -

 

 

紡錘細胞腫瘍

 

  MS
Actin
SM
Actin
ALDH1A1 BG8 CD10 CD31 CD34 CD99 Collagen
IV
CK
8&18
Angiosarcoma - - - - - + + -   -
Atypical Fibroxanthomas + + + - + - - + - -
Dermato broma Fibrous Histiocytoma - - -   +   - - -  
Dermatofibrosarcoma Protuberans - - -    +/-   + - -  
DF-FH - - -   + - - - - -
DF-SP - - - -  +/- - + - - -
Glomus Tumor + + -   - -  +/- - + -
Hemangioma - + - + - + + - + -
Hemangiopericytoma - - +   - + +   -  
Kaposi’s Sarcoma - + - - - + + -  +/- -
Kaposiform Hemangioendothelioma - - - - - + + - -  
Peripheral Nerve Sheath + - + - - - - + +  
Smooth Muscle + + +   - - - -/+ - -
Solitary Fibrous Tumor - - + - - - +  +/- - -
Spindle Cell Melanoma - - - - - - - - - -
Spindle Squamous Cell Carcinoma - - - - - - - - - +
Squamous Cell Carcinoma - - -   - - - - -  

 

 

紡錘細胞腫瘍 (続き)

 

  CK
Cocktail
Factor
VIII
Factor
XIIIa
FLI-1 HHV-8 NGFR D2-40 S-100 STAT6
Angiosarcoma - +   + - -  +/- - -
Atypical Fibroxanthomas - -  +/- - - - - - +
Dermato broma Fibrous Histiocytoma     + -   - - - -
Dermatofibrosarcoma Protuberans     -     + - - -
DF-FH   - + - - - - - -
DF-SP   - - - - + - - -
Glomus Tumor   - - - - - - - -
Hemangioma - +   + - - - - -
Hemangiopericytoma   -   + - - - - +
Kaposi’s Sarcoma   +  +/- + + - + - -
Kaposiform Hemangioendothelioma   - - + - -   - -
Peripheral Nerve Sheath - - - - - + +  +/- -
Smooth Muscle - - - - - - - - -
Solitary Fibrous Tumor   - - -/+ - - - - -
Spindle Cell Melanoma - - - + - + + + -
Spindle Squamous Cell Carcinoma + -   - - - + - -
Squamous Cell Carcinoma   - - - - - + - -

 

 

 

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胃腸病理

 

 

 

膨大部がん

 

  CDX-2 MUC2 CK 17 MUC1
Intestinal Subtype + + - -
Ductal - - + +

 

 

GIST

 

  CD34 CD117 DOG1
GIST, Kit Mutation + + +
GIST, PDGFRA Mutation - - +
GIST, Wild Type  +/- + +

 

 

脾臓/脾臓腫瘍

 

   β-Catenin CA 19-9 D10 CD56 CDX-2 Synaptophysin CK 7 CK 19 E-cadherin
Ductal Adenocarcinoma / Ductal Carcinoma  +/- +  +/- - - - + -  +/-
Pancreatic Adenocarcinoma - +  +/- -   -   + -
Pancreatic Endocrine Tumor     - + -    
Acinar Cell Carcinoma + -/+  +/- - - - - + +
Pancreatoblastoma + - - +   +   - -
Neuroendocrine Tumor +  +/- - +   +    +/- -
Solid Pseudopapillary Tumor + - + +   -   -  +(核)
Islet Cells + - - +   +   - -
Pancreatic Ducts - - - - - - + - -

 

 

 

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泌尿生殖器病理

 

膀胱組織

 

  SM
Actin
MS
Actin
Calponin Smoothelin
Muscularis Mucosae + + + -
Muscularis Propria + + + +

 

 

膀胱:形成異常 vs 反応性

 

  CD44 CK 20 CK 5&6 Ki-67 MCM3 p53
Carcinoma-in-situ - + - + + +
Reactive Atypia + - + + + -
Normal Urothelium + + -/+ -/+ -/+ -

 

 

がん

 

  CD10 CD117 CK 7 CK, HMW Ksp-cadherin RCC S100P TFE3
Xp11 Tr RCC +   -/+   + + - +
Clear Cell RCC + - -/+ - -/+ + - -
Papillary RCC + - +  +/- -/+ + - -
Chromophobe RCC  +/- + + - + + - -
Oncocytoma + + -/+ -/+ + - - -
Urothelial Carcinoma +  +/- +  +/- - - + -

 

 

 

胚細胞腫瘍

 

  AFP CD30 CD117 CK
Cocktail
EMA GPC-3 hCG hPL Inhibin
Seminoma (Seminoma/Dysgerminoma) - - + - - - - - -
Embryonal Carcinoma - + - + - - - - -
Choriocarcinoma - - - + + + + + -
Yolk Sac Tumor + - -/+ + - + - - -
Granulosa Cell Tumor - - - - - - - - +
Hypercalcaemic Small Cell Carcinoma - - - + + - - - -
Mature Teratoma  +/- - - + + - - -/+  
Immature Teratoma - -  +/- + + -  +/- -/+  
Carcinoid - - - + - - - - -

 

 

胚細胞腫瘍 (続き)

 

  Oct‐4 PLAP D2-40 SALL4 SOX-2 Synaptophysin Vimentin
Seminoma (Seminoma/Dysgerminoma) + + + + - - +
Embryonal Carcinoma + + - + + - -
Choriocarcinoma - + - - - - -/+
Yolk Sac Tumor - -/+ - + - - -
Granulosa Cell Tumor - -  +/- -   - +
Hypercalcaemic Small Cell Carcinoma - - +     - -
Mature Teratoma -  +/- - -  +/- - +
Immature Teratoma - - -  +/- + - +
Carcinoid - - - - - + +

 

 

 

生殖腺:胚細胞腫瘍 vs 体細胞腫瘍

 

  AFP CD30 CD117 CK
Cocktail
EMA GPC-3 hCG hPL Inhibin
Seminoma - - + - - - - - -
Embryonal Carcinoma -   - + - - - - -
Choriocarcinoma - - - + + + + + -
Yolk Sac Tumor + - - + - + - - -
Somatic Carcinoma - - - + + - - - -
Granulosa Cell Tumor - - - - - - - - +
Hypercalcaemic Small Cell Carcinoma - - - + + - - - -

 

 

 

生殖腺:胚細胞腫瘍 vs 体細胞腫瘍 (続き)

 

  43012 PLAP D2-40 Vimentin
Seminoma + + + +
Embryonal Carcinoma + + - -
Choriocarcinoma - + - -/+
Yolk Sac Tumor - + - -
Somatic Carcinoma - - -/+ -
Granulosa Cell Tumor - -  +/- +
Hypercalcaemic Small Cell Carcinoma - - + -

 

 

 

 

 

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頭部および頸部病理

 

副甲状腺腫瘍 vs 甲状腺腫瘍

 

  Calcitonin PAX-8 Chromogranin
A
PTH S-100 Galectin-
3
Synaptophysin TTF-1
Parathyroid Tumors - + + + - - + -
Follicular Thyroid Tumors - + - -  +/- + - +
Medullary Thyroid Cacinoma + - + - - - + +

 

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血液病理

 

B細胞リンパ腫

 

  Annexin
AI
BCL2 BCL6 BOB.1 CDS CD10 CD11c CD20 CD23 CD25
Burkitt Lymphoma - - + + - +   + -  
CLL/SLL - + - -/+ + - -/+ + +  
Diffuse Large Cell Lymphoma - +  +/- + -/+     + -  
Follicular - + + + - +   + - -
Hairy Cell Leukemia + + -   - - + + - +
Lymphoplasmacytic - + - + - - - + - -
Malt Lymphoma   + -/+     -   + -  
Mantle Cell - + - -/+ + - - + - +
Marginal Zone - + -   - -   + - -
Marginal Zone BCL - + - -/+ - -   + -  
Splenic Marginal Zone - + -   - -     -  

 

 

 

B細胞リンパ腫 (続き)

 

  CD43 CD45 CD79a Cyclin
D1
FoxP1 IgD Kappa Lambda MUM1 Octー2
Burkitt Lymphoma   + + - + -  +/- -/+ - -
CLL/SLL + + + - - +  +/- -/+ + +
Diffuse Large Cell Lymphoma - + + - + -  +/- -/+  +/- +
Follicular   + + - - +  +/- -/+ - +
Hairy Cell Leukemia - + +  +(weak)/-   -  +/- -/+    +(weak)/-
Lymphoplasmacytic   + + - - -  +/- -/+ + -
Malt Lymphoma     + - +       -  
Mantle Cell + + + + - + -/+ -/+ - +
Marginal Zone + + + -   + -/+ -/+ + +
Marginal Zone BCL     + -   -/+     + +
Splenic Marginal Zone     + - -        +/- +

 

 

 

B細胞リンパ腫 (続き)

 

  p27 PAX-5 PD-1 PU.1 TRAcP ZAP-70
Burkitt Lymphoma - + -   - -
CLL/SLL + + - + -  +/-
Diffuse Large Cell Lymphoma - + - + - -
Follicular + + + + - -
Hairy Cell Leukemia - + -   + -
Lymphoplasmacytic +   -   - -
Malt Lymphoma            
Mantle Cell + + - + - -
Marginal Zone   + - +  +/- -
Marginal Zone BCL + +   +  +/-  
Splenic Marginal Zone   -        

 

 

c-Myc (びまん性大細胞型B細胞リンパ腫)

 

  BCL2 CD10 CD38 CD44 TCL1
Large B-cell Lymphoma with c-Myc Rearrangement -/+ + + - +
Large B-cell Lymphoma with no c-Myc Rearrangement +  +/- - + -/+

 

 

赤血球

 

  CD71 Glycophorin
A
Hemoglobin
A
Spectrin
Erythroid Hyperplasia + + + +
Erythroid Hypoplasia + + + +
Acute Erythroid Leukemia + + + +
Extramedullary Hematopoiesis + + + +
Mature Erythrocytes - + + +

 

 

組織球増殖

 

  CD1a CD68 CD163 Factor
XIIIa
HAM-56 lysozyme S-100 Vimentin
Juvenile Xanthogranuloma - + + + + + - +
Langerhans Cell Histiocytosis + + + - + + + +
Dermatofibroma - + - + - - - +

 

 

ホジキンリンパ腫 vs 非ホジキンリンパ腫

 

  EMA Fascin Granzyme
B
MUM1 Octー2 PU.1
Anaplastic Large Cell Lymphoma + - + - - -
Angioimmunoblastic T-cell Lymphoma - - - - - -
Hodgkin Lymphoma, Classic - + - + - -
Hodgkin Lymphoma, Nodular Lymphocyte Predominant + - - -/+ + +
T-cell Rich B-cell Lymphoma -/+ - - + + -
T-cell Rich LBCL - - - + + -

 

 

イムノグロブリン(重鎖、軽鎖)

 

  IgA IgD IgG IgM Kappa Lambda
Cutaneous Lymphoma - - - -  +/- -/+
Myeloma + -/+ + -/+  +/- -/+
Diffuse LBCL - - + +  +/- -/+
Marginal Zone Lymphoma - -/+ - +  +/- -/+
SLL/CLL - + - +  +/- -/+

 

白血病

 

  CD13 CD14 CD16 CD33 CD34 CD38 CD71 CD117 CD163 MPO
Acute Myeloid Leukemia with Minimal Differentiation + + - + + + - + - -
Acute Myeloid Leukemia without Maturation + - - + + - - + - +
Acute Myeloid Leukemia with Maturation + - - + + - - + - +
Acute Myelomonocytic Leukemia + + + +  +/- - - + + +
Acute Monoblastic and Monocytic Leukemia + + + + -/+ - -  +/- + +
Acute Erythroid Leukemia - - - - -/+ - +  +/- - -
Acute Megakaryoblastic Leukemia  +/- - -  +/- - - - - - -
Acute Basophilic Leukemia + - - +  +/- - - - - -
Acute Panmyelosis with Myelofibrosis + - - + + - - + - -

 

 

 

リンパ節

 

  CD1a CD14 CD21 CD35 CD68 CD163 Lysozyme PD-1 S-100
Reactive Histiocytosis - + - - + - + - -
Langerhans Cell Histiocytosis + + - - + + + - +
Sinus Histiocytosis with Massive Lymphadenopathy - + - - + + + - +
Follicular Dendritic Cell Sarcoma  +/- - + + - - - - -
Dermatopathic Lymphadenitis + - - - - + + - +

 

 

 

 

リンパ芽球性リンパ腫 BCL vs TCL

 

  CD1a CD3 CD5 CD7 CD10 CD19 CD20 CD74 CD117 PAX-5 TdT
Lymphoblastic BCL - - - -  +/- +  +/- + - + +
Lymphoblastic TCL  +/- +  +/- + + - - - - - +

 

 

リンパ腫

 

  CD3 CD20 CD43 CD45R CD45RO
Mature B-cell - + - + -
Mature T-cell + - + - +

 

 

リンパ腫

 

  CD20 CD30 CD38 CD45 CD79a CD138 EMA HHV-8 MUM1 PAX-5
Plasmablastic Lymphoma - + + - + + + - + -
Primary Effusion Lymphoma -  +/-  +/- + - +  +/- + + -
Large B-cell Lymphoma arising in HHV8-associated Multicentric Castleman Disease -/+   -/+ + - -   + + -
Extranodal Marginal Zone Lymphoma with Plasmacytoid Differentiation -   + + + +       -

 

 

リンパ腫

 

  Granzyme
B
Perforin TIA-1
NK/T Cell Lymphoma + + +
Hepatosplenic T-cell Lymphoma - - +
Cutaneous T-cell Lymphoma + + +
EBV+ Systemic T-lymphoproliferative Disorders + + +
T-cell Large Granular Lymphocytic Leukemia + + +
Adult T-cell Leukemia/Lymphoma - - -
Marginal Zone - - -
Marginal Zone BCL + + +

 

 

 

リンパ腫

 

  BCL2 BCL6 CD15 CD30 Cyclin
D1
Granzyme
B
IMP3 MUM1
Classical Hodgkin’s Lymphoma + - + + - - + +
Lymphocyte Predominant Hodgkin Lymphoma + + - - - - + -/+

 

 

リンパ腫

 

  PAX-5 SOX-11
Classical Hodgkin’s Lymphoma + -
Lymphocyte Predominant Hodgkin Lymphoma + -

 

 

 肥満細胞症

 

  CD2 CD25 CD117 CD163 Tryptase
Mastocytosis / Systemic Mastocytosis + + + - +
Mast Cell Leukemia + + + - +
Reactive Mast Cells - - + + +

 

 

成熟B細胞リンパ腫

 

  Annexin
A1
BCL2 CD5 CD10 CD20 CD23 HGAL LMO2 Cyclin
D1
Follicular Lymphoma -  +/- -  +/- + - + + -
Diffuse Large B-cell Lymphoma - + -/+  +/- + - + + -
Small Lymphocytic Lymphoma - + + - + + - - -
Mantle Cell Lymphoma - + + - + - - - +
Marginal Zone Lymphoma - + - - + - - - -
Hairy Cell Leukemia + + - - + -     -

 

 

 

成熟B細胞腫瘍

 

  Annexin
A1
CD10 CD11c CD25 CD103 CD123 CyclinD1 DBA44 T-bet TRAcP
Hairy Cell Leukemia + + + + + +  +(weak)/-  +/- +  +/-
Hairy Cell Leukemia Variant - - + -  +/-      +/- -  +/-
Splenic Marginal Zone Lymphoma - - -/+ - - - -  +/- -  +/-

 

 

NK細胞 白血病/リンパ種

 

  CD2 CD3 CD16 CD56 CD57 Granzyme
B
Perforin TIA-1
Aggressive NK-Cell Leukemia + + + + - + + +
T-Cell Large Granular Lymphocytic Leukemia + + + - + + + +
Extranodal NK/T-Cell Lymphoma, Nasal Type + + - + - + + +

 

 

 

非ホジキンリンパ腫

 

  CD5 CD10 CD20 CD23 Cyclin
D1
SOX-11
MCL + - + - + +
FL - + + - - -
SLL/CLL + - + + - -
MZL - - + - - -
LBL -  +/- + - - -
BL - - + - - -/+
CD5+ DLBCL + + + - - -
Blastoid Variant MCL +   + - + +

 

 

 

形質細胞腫瘍とリンパ球増殖腫瘍

 

  CD19 CD20 CD43 CD56 CD79a CD138 Cyclin
D1
EMA MUM1
Plasma Cell Neoplasm - -/+ - + + + -/+ + +
ALK + LBCL - -   - - + - + +
Plasmablastic Lymphoma - - - - + + - + +
HHV Associated LBCL  +/-  +/- - - - - - - -
Primary Effusion Lymphoma - - - - - + - + +
Lymphoblastic Lymphoma + + - - + + - -  +/-
Splenic Marginal Zone Lymphoma + + - - + -/+ - -  +/-

 

 

脾造血増殖 Splenic Hematopoietic Proliferations

 

  CD34 CD68 CD117 Hemoglobin
A
MPO
Chronic Myelogenous Leukemia -/+ +  +/- - +
Chronic Idiopathic Myelofibrosis  +/-   -/+ - +
Myelodysplastic Syndrome +   -/+ -  
Myelodysplastic/Myeloproliferative Disorders - + - - +
Mastocytosis -   + - +
Erythroid Disorders -   - +  +/-
Splenic Lymphoma -   - - -/+
Acute Myeloid Leukemia + + + - +
Polycythemia Vera +   + +  

 

 

T細胞リンパ腫

 

  CD56 CD57 Granzyme
B
PD-1 Perforin TCL1
Angioimmunoblastic     - +    
Lymphoblastic      +/- -    
Subcutaneous Panniculitis-Like -   + - +  
NK/T-cell Lymphoma +  +/- + - + +
Cutaneous     + -/+ +  
Peripheral, NOS - -   -    
Mycosis Fungoides -    +/- - -  

 

 

 

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神経病理

 

脳:CNS腫瘍1

 

  EMA CK, pan GFAP Vimentin Olig2 S-100
Astrocytoma - - + +  +/- +
Oligodendrocytoma - - - + + -
Glioblastoma - +  +/- + + +
Ependymoma - +  +/- - - +
Meningloma + -  +/- +  +/- -/+

 

 

 

 

脳:CNS腫瘍2

 

  CK
Cocktail
EMA GFAP INI-1 NGFR Neurofilament PR S-100 Synaptophysin Vimentin
Astrocytoma - - + + + - - + - +
Glioblastoma - - + + - - - + - +
Oligodendriglioma - - - + - - - + - +
Ependymoma - - + + + - - + -  
Choroid Plexus Carcinoma + - -/+ + - - - + +  +/-
Central Neurocytoma - - - + + - - - + -
Neuroblastoma - -  +/- + + + -   + -/+
Pineocytoma - - - + - - - - + +
Meningloma - + - + - - + - - +
Schwannoma - - + + + - - + - +
Rhabdoid Tumors + + - -    +/-    +/-  +/- +
Metastatic Carcinoma + + - + - - -/+ - - -/+

 

組織学的模倣による髄膜腫

 

  ALDH1A1 CD34 Claudin-1 EMA E-cadherin GFAP S-100 STAT6
Meningothelial Meningioma - - + + + - - -
Atypical Meningioma - + + + + - - -
Fibrous Meningioma - - - + + - + -
Solitary Fibrous Tumor + + - - - - - +
Meningeal Hemangiopericytoma + + - - - - - -/+
Schwannoma -  +/- - + + + -

 

 

後腹膜腫瘍

 

  CD99 Chromogranin
A
GFAP MBP Neurofilament NSE PGP 9.5 S-100 Synaptophysin
Neuroblastoma - +  +/- - + + + - +
Ganglioneuroblastoma - + + -/+ + + + + +
Ganglioneuroma - + + + + + + + +

 

 

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小児科病理

 

組織球増殖

 

  CD1a CD68 CD163 Factor
XIIIa
HAM-56 Lysozyme S-100 Vimentin
Juvenile Xanthogranuloma - + + + + + - +
Langerhans Cell Histiocytosis + + + - + + + +
Dermatofibroma - + - + - - - +

 

 

後腹膜病変

 

  Chromogranin
A
CD99 GFAP Neurofilament NSE PGP 9.5 S-100 Synaptophysin
Neuroblastoma + - -/+ + + + - +
Ganglioneuroblastoma + - + + + + + +
Ganglioneuroma + - + + + + + +
Leiomyosarcoma - - - - -/+ -/+ - -
Rhabdomyosarcoma - - - - - + - -
Synovial Sarcoma -  +/- - - -   -/+ -

 

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肺病理

 

肺腺がん vs 中皮腫

 

  BGB Caldesmon Calretinin CEA CK 5&6 Ber-EP4
Adenocarcinoma + - - + - +
Mesothelioma - + + - + -

 

肺腺がん vs 中皮腫 (続き)

 

  E-cadherin HBME-1 D2-40 TAG-72 TTF-1
Adenocarcinoma + - - + +
Mesothelioma - + + - -

 

肺扁平上皮がん vs 腺がん

 

  CK 5&6 Desmocollin3 Napsin
A
p63 SOX-2 TTF-1
Lung Adenocarcinoma - - + -/+ -/+ +
Lung Squamous Cell Carcinoma + + - + + -

 

胸膜: 肺腺がん vs 中皮腫

 

  Caldesmon Calretinin CEA CK 5 CK 5&6 Ep-CAM E-cadherin HBME-1 Napsin
A
D2-40
Adenocarcinoma - - + - - + + - + -
Mesothelioma + + - + + - - + - +

 

胸膜: 肺腺がん vs 中皮腫 (続き)

 

  TAG-72 TTF-1 TBM WT1
Adenocarcinoma + + - -
Mesothelioma - - + +

 

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軟部組織病理

 

組織球性細胞損傷/樹状細胞損傷

 

  CD1a CD21 CD23 CD35 CD68 CD163 Langerin Lysozyme S-100
Langerhans Cell Histiocytosis + - - - + + +  +/- +
Rosai-Dorfman Disease - - - - + + - + +
Follicular Dendritic Cell Sarcoma - + + +  +/-  +/- - - -
Interdigitating Dendritic Cell Sarcoma - - - -  +/- + - + +
Histiocytic Sarcoma - - - - + + - +  +/-
Juvenile Disseminated Xanthogranuloma - - - - + + - +  +/-

 

筋悪性腫瘍

 

  SM
Actin
MS
Actin
Myogenin PGP 9.5 Caldesmon Myoglobin Calponin Vimentin INI-1
Leiomyosarcoma + + - - + - + + -
Rhabdomyosarcoma -/+ -/+ + + - + - + +

 

 

小型類円形細胞腫瘍

 

  MS
Actin
SM
Actin
Caldesmon Calponin CD45 CD57 CD99 CK
Cocktail
FLI-1
Lymphoblastic Lymphoma - - -   + - + - +
Leiomyosarcoma + + + + -  +/- - -/+ -
Rhabdomyosarcoma - - - - - - - - -
Neuroblastoma - - -   - + - - -
Embryonal Carcinoma - -     - + - + -
PNET/ES - -     - + + -/+ +
DSRCT - -     -  +/- - + +
Medulloblastoma - -     - + - - -

 

小型類円形細胞腫瘍 (続き)

 

  INI-1 Myogenin Myoglobin PGP 9.5 Vimentin WT1
Lymphoblastic Lymphoma + - -   + -
Leiomyosarcoma - - - + -
Rhabdomyosarcoma + + + + + -
Neuroblastoma + - - + + -
Embryonal Carcinoma + - - + - -
PNET/ES + - - + + -
DSRCT + - - - + +
Medulloblastoma + -     -  

 

 

軟部組織新生物

 

  MS
Actin
SM
Actin
Calretinin CD34 CD56 CK
Cocktail
Desmin HMB-45 S-100 TFE3
Alveolar Soft Part Sarcoma + + - - - - - - - +
Clear Cell Sarcoma - - - - - - - + + -
Leiomyosarcoma + + - -/+ + -/+ + - - -
PEComa - + + - + - - + + -

 

 

軟部組織肉腫

 

  MS
Actin
SM
Actin
Calponin Calretinin CD34 CD56 CD99 CK
Cocktail
Desmin EMA
Alveolar Soft Part Sarcoma + +   - - - - - - -
Clear Cell Sarcoma - -   - - - - -    
Desmoplastic Small Round Cell - -   - - - - +    
Epithelioid Sarcoma -/+ - - - + - - + - +
Leiomyosarcoma + +     -/+ +   -/+ + -/+
Mesenchymal Chondrosarcoma - -   + -/+ - + -    
Myxoid Chondrosarcoma -    +/- + -/+ -   -   -
PEComa - +   + - - - -    
PNET/ES - -   - - - + -/+    
Rhabdomyosarcoma -/+ -/+     - +   - + -
Synovial Sarcoma - - -  +/- - + + + - +

 

 

軟部組織肉腫 (続き)

 

  Myogenin S-100 TFE3 TLE1
Alveolar Soft Part Sarcoma - - + -
Clear Cell Sarcoma   + - -
Desmoplastic Small Round Cell   - - -
Epithelioid Sarcoma -   - -
Leiomyosarcoma -   -  
Mesenchymal Chondrosarcoma    +/- - -
Myxoid Chondrosarcoma       -
PEComa   - - -
PNET/ES   + - -
Rhabdomyosarcoma +   -  
Synovial Sarcoma - -/+ - +

 

 

軟部組織腫瘍

 

  MS
Actin
SM
Actin
ALK Calponin CD34 CD99 CK
Cocktail
Desmin EMA FLI-1
Alveolar Soft Part Sarcoma + + -   - - - -    
Clear Cell Sarcoma - - -   - - -      
Desmoplastic Small Round Cell - - -   - - + + -  
Epithelioid Sarcoma -/+ - -   + - + - +  
Fibrous Histiocytoma - + -     - - -    
Inflammatory Myo broblastic Tumor + + +   - - -      
Leiomyosarcoma + +   +   - -/+     -
Myxoid Chondrosarcoma - - -   -/+   - - -  
PEComa - + -     - -  +/-    
PNET/ES - - - - - + -/+ -   +
Rhabdomyosarcoma -/+ -/+   -   - -     -
Synovial Sarcoma - - -   - + + - +  

 

 

 

軟部組織腫瘍 (続き)

 

  INI-1 Myogenin PGP 9.5 S-100 TFE3 TLE1
Alveolar Soft Part Sarcoma       - + -
Clear Cell Sarcoma       + - -
Desmoplastic Small Round Cell       - - -
Epithelioid Sarcoma       - - -
Fibrous Histiocytoma       - - -
Inflammatory Myo broblastic Tumor       - - -
Leiomyosarcoma   - -      
Myxoid Chondrosarcoma        +/- - -
PEComa       - - -
PNET/ES + - + + - -
Rhabdomyosarcoma + + +      
Synovial Sarcoma       - - +

 

血管腫瘍

 

  CD34 ERG Factor
VIII
FLI-1 HHV-8 D2-40
Hemangioma + + + + - -
Kaposi’s Sarcoma + + + + + +
Hemangioendothelioma + + - + - -
Angiosarcoma + + + + -  +/-
Colorectal Adenocarcinoma - - - -/+ - -
Invasive Ductal Carcinoma - - -/+ - -

 

 

 


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