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More details about licensing

All of their products have adopted a new dongle licensing scheme (for PC and MAC). It make the user change the computer freely with taking this USB key in his office and in his home.

in silico MolecularCloning, IMC, series products feature various cloning experiments on computer. Cloning experiments involves the fundamental experiments such as digestion with a restriction enzyme, PCR primer designing, PCR amplification and Ligation. You don’t need any particular data for these functions, and you can easily use the base sequence data obtained from the official database like GenBank and/or EMBL for your cloning experiments. During the cloning, the restriction enzyme digestion fragment and configuration of the end (like sticky end, blunt end) will be kept precisely, and you can activate just the ligation of the fragments which have the same configurations and complementary sequences. As the primer information is attached and saved on the base sequence, it is very convenient for controlling the primer.

This software is designed to perform the NCBI Blast easily. By only loading the annotated base sequence files of whole genome, the Blast database of whole CDS will be automatically generated, and just a click of feature make the program perform the NCBI Blast. The result will be displayed graphically. The alignment indication is also available. Further, the program prepares for the sequence pattern searches, keyword searches, feature key searches and EC number searches for your convenience.
All operations can be performed by drags and clicks with mouse and/or many different kinds of buttons on the toolbar, which can be said the simple and easy human interface.
You can also map the sequencing data by ABI/SCF format onto the genome DNA and the alignment with trace patterns can be displayed.

The base sequence files of cDNA will be registered as the feature with differentiating exon from intron when it will be mapped onto the genome sequences. You can easily perform the annotation with referring the existing annotation, the result of NCBI Blast and/ or base /amino acid sequences, through the annotation windows.
With using Batch Homology Search function, you can perform the sequential NCBI Blast with querying the all features located in the designated domain, and can transcript the search result as the annotation automatically.
The standard edition of IMC includes fundamental functions for the study of molecular biology, such as NCBI Blast function, pattern search function and annotation function, besides the cloning functions.

MetaGenome GAMBLER (MGG) series Lite Edition is used in the Microbial genome sequencing project. This program offers many kinds of functions with additional using of in silico Assembler (sold separately).
With MGG, you can perform assemble-and-go and sequencing analysis with mixing the raw data by conventional type sequencer and/or various format of sequence data. The graphical functions are built in for the quality control of sequences. The result of assembling shown by alignment of each base fragments can be watched and edited by the Alignment viewer/editor built in the program. Further, Fragment viewer shows the overall and regional binding state of contig, and displays graphically the overlapping situation of each fragment.
These are the fundamental functions of Lite Edition of MGG.

Professional Edition of MGG has the additional functions like mapping the sequence data by the next-generation sequencer such as 454, Solexa and SOLId on to the well-knwon reference genome and re-sequencing it. And the histogram of redundancy of mapping correlated with the reference genome sequence will be generated. You can export this data to IMC and watch it in comparison with the known annotation and/or array expression profiling. And Professional Edition has the clustering functions.

MGG products have adopted a new dongle licensing scheme (for PC and MAC). It make the user change the computer freely with taking this USB key in his office and in his home.

in silico Assember is a low-cost assemble software. This program has the functions such as mapping by the data from next-generation sequencer, re-sequencing. This program is supplied as the bundle software of MetaGenomeGAMBLER (MGG) and can be called up from MGG. It is not prepared for the single use interface.

Currently it becomes difficult to obtain the proper data such as base sequence data, amino acid sequence data to use them for the targeted analysis because the gargantuan amount of data are stored in the world. To resolve this issue, you need to be clued up

how to use the website where these data are supplied and frequently updated. But it is much bothersome task to check these database frequently, unless it is his/her daily task. And it is also necessary to save these frequently updated data in the local computers, it is some arduous works too. In silico biology,Inc has developed Spider Series softwares to support these annoying tasks.