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IMMUNIS HBV Genotype EIA
URL : http://www.tokumen.co.jp/english/
EIA kit for serological determination of HBV genotype
There are eight genotypes (genotype A to H) of hepatitis B virus (HBV) which are distinguished by > 8 % difference in the nucleotide sequence of the HBV genome 1, 2). Genotypes A and D are common in Europe and the United States, while genotypes B and C are prevalent in Asia. Genotype F is frequent in Latin America, while genotype E is confined to Central and Western Africa.
Many studies indicate that HBV genotypes influence the severity of chronic hepatitis B and the response to interferon therapy. HBV genotypes have been determined by tedious methods such as direct sequencing, genotype-specific PCR, PCR-RFLP, line-probe assay (LiPA), or PCR-invader assay.
This product is an enzyme immunoassay (EIA) based HBV genotyping kit, designed to determine genotype (A, B, C, or D) by detecting genotype-specific epitopes in PreS2 region 3-5).
Note: This product is intended to be used only for research purpose outside Japan.
- Application
- Hepatitis B Virus serological genotyping in human serum (Genotype A, B, C, or D)
- Features
-
- ● The first diagnostic reagent for determination of HBV genotype launched in the Japanese market
- ● Fast and easy detection based on one-step EIA method
- ● 98% of samples with HBsAg concentration of >3 IU/mL can be genotyped (unpublished data)
- ● Sample volume: 80μL of HBsAg positive serum
- ● Stored sample can be used
- ● 4 wells/sample
- ● Reaction time: 2.5 hours
- Product Name
- IMMUNIS® HBV Genotype EIA
- Product Code
- 1A65
- Package
- 48 tests
- References
-
- Okamoto H, Tsuda F, Sakugawa H, et al:Typing hepatitis B virus by homology in nucleotide sequence:comparison of surface antigen subtypes. J Gen Virol 69:2575-2583, 1988.
- Arauz-Ruiz P, Norder H, Robertson BH, et al:Genotype H:a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol 83:2059-2073, 2002.
- Usuda S, Okamoto H, et al: Serological detection of hepatitis B virus genotypes by ELISA with monoclonal antibodies to type-specific epitopes in the preS2-region product. J Virol Methods 80：97-112, 1999.
- Moriya T, Kuramoto IK, Yoshizawa H, et al: Distribution of hepatitis B virus genotypes among American blood donors determined with a PreS2 epitope enzyme-linked immunosorbent assay kit. J Clin Microbiol. 40: 877-880, 2002.
- Tanaka Y, Sugauchi F, Matsuura K, et al: Evaluation of hepatitis B virus genotyping EIA kit. Rinsho Byori. 57: 42-47, 2009.
